MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4. Kriegel and Colleagues, Kidney Int. 2017. Cardiovascular events are the leading cause of death in patients with chronic kidney disease (CKD), although the pathological mechanisms are poorly understood. Here we longitudinally characterized left ventricle pathology in [...]
Tissue-Specific MicroRNA Expression Patterns in Four Types of Kidney Disease Liang and Colleagues, J Am Soc Nephrol. 2017. MicroRNAs contribute to the development of kidney disease. Previous analyses of microRNA expression in human kidneys, however, were limited by tissue heterogeneity or the inclusion of only one pathologic type. In this study, we used laser-capture [...]
Hypertension: from GWAS to functional genomics-based precision medicine Mattson and Colleagues, Nat Rev Nephol. 2017 Functional genomics in disease-relevant tissues is essential for advancing precision medicine for common and complex diseases. A) Hypertension and other common and complex cardiovascular and renal diseases are heavily influenced by environmental factors, which might be difficult to identify [...]
Association of TMTC2 With Human Nonsyndromic Sensorineural Hearing Loss Runge and Colleagues, JAMA Otolaryngol Head Neck Surg. 2016 IMPORTANCE: Sensorineural hearing loss (SNHL) is commonly caused by conditions that affect cochlear structures or the auditory nerve, and the genes identified as causing SNHL to date only explain a fraction of the overall genetic [...]
The Human Microcirculation: Regulation of Flow and Beyond Gutterman and Colleagues, Circ Res. 2016 The microcirculation is responsible for orchestrating adjustments in vascular tone to match local tissue perfusion with oxygen demand. Beyond this metabolic dilation, the microvasculature plays a critical role in modulating vascular tone by endothelial release of an unusually diverse family of [...]
Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation Beyer and Colleagues, Circ Res. 2016. To prevent DNA loss during mitosis, nature has cleverly placed telomeres on the ends of chromosomes to function as disposable nucleotide sequences. Telomeres do, however, shorten with progressive cell division and without a [...]
The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility. Benjamin and Colleagues, J Biol Chem. 2016 Mutations of HSPB5 (also known as CRYAB or αB-crystallin), a bona fide heat shock protein and molecular chaperone encoded by the HSPB5 (crystallin, alpha B) gene, are linked to multisystem disorders [...]
Characteristics of long non-coding RNAs in the Brown Norway rat and alterations in the Dahl salt-sensitive rat Liu and Colleagues, Sci Rep. 2014 Read more here.
Ushering Hypertension Into a New Era of Precision Medicine Liang and Colleagues, JAMA 2016 In a Viewpoint article published in the January 26, 2016, issue of JAMA, Ted Kotchen, Allen Cowley (a CoSMM member), and Mingyu Liang (CoSMM Director) made the case that precision medicine needs more than DNA sequences and epigenomic analysis can [...]
Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats Geurts and Colleagues, Hypertension. 2015 Maternal diet modified the severity of salt-induced hypertension. To read more click here.