FAQ2020-12-15T23:17:50+00:00

 NEWS

Center of Systems Molecular Medicine (CoSMM) invited speaker – Anna Greka, MD, PhD2022-02-03T21:21:52+00:00

Greka Flyer

Center of Systems Molecular Medicine (CoSMM) invited speaker  – Anna Greka, MD, PhD Associate Professor of Medicine, Harvard Medical School.  Presents “Integrative Systems Approaches Probing Disrupted Cellular Homeostasis” on Thursday, March 17th, 2022 (Virtual).

Dr. Pradeep Chaluvally-Raghavan received the 2022 Molecular Systems Medicine Excellence Award2022-02-18T19:23:44+00:00

Dr. Pradeep Chaluvally-Raghavan received the 2022 Molecular Systems Medicine Excellence Award

Dr. Pradeep Chaluvally-Raghavan, Associate Professor in the Department of Obstetrics and Gynecology, has been awarded a 2022 Molecular Systems Medicine Excellence Award from the Center of Systems Molecular Medicine (CoSMM) at the Medical College of Wisconsin.  The award includes discretionary funds and a plaque.

The Molecular Systems Medicine Excellence Award is given to CoSMM faculty members with high-profile, senior-authored original research publications relevant to the discipline of molecular systems medicine.  Any MCW faculty members who are interested in more information about the award or CoSMM membership are welcome to contact Kristin Nord.

Center of Systems Molecular Medicine (CoSMM) invited speaker – Pradeep Natarajan, MD2021-10-29T16:06:10+00:00

Natarajan Flyer

Center of Systems Molecular Medicine (CoSMM) invited speaker  – Pradeep Natarajan, MD Associate Professor of Medicine, Harvard Medical School – Broad Institute.  Presents “Clonal hematopoiesis of indeterminate potential and risk for atherosclerotic cardiovascular disease” on Monday, November 22nd, 2021 (Virtual).

CoSMM investigators and collaborators obtained a $11.8 million Program Project Grant to study genetics and epigenetics2020-12-15T21:53:56+00:00

Center of Systems Molecular Medicine (CoSMM) invited speaker – Maggie Chen, MD, PhD2020-06-03T18:24:40+00:00

Center of Systems Molecular Medicine (CoSMM) invited speaker  – Maggie Chen, MD, PhD Associate Professor, Division of Nephrology, Washington University School of Medicine.  Presents “Targeting Podocyte Endoplasmic Reticulum to Treat Nephrotic Syndrome” on Thursday, July 23rd, 2020 (Virtual).

Center of Systems Molecular Medicine (CoSMM) invited speaker – Markus Bitzer, MD2019-10-11T16:25:51+00:00

Center of Systems Molecular Medicine (CoSMM) invited speaker  – Markus Bitzer, MD, Clinical Associate Professor, Department of Internal Medicine, Division of Nephrology, University of Michigan.  Presents “Post-transcriptional Regulation of Gene Expression by microRNAs in the Kidney” on Wednesday, October 23rd,  2019 in H1210/1230.

Center of Systems Molecular Medicine (CoSMM) invited speaker – Rafael Yuste, MD, PhD2019-10-11T16:16:01+00:00

Center of Systems Molecular Medicine (CoSMM) invited speaker  – Rafael Yuste, MD, PhD, Professor, Departments of Biological Sciences and Neuroscience, Columbia University.  Presents “The NeuroRights Initiative: Human Rights Guideline for Neurotechnology and AI” on Monday, October 21st,  2019 in A1015/1035.

Center of Systems Molecular Medicine (CoSMM) invited speaker – Ayako Makino, PhD2019-08-01T20:16:58+00:00

Center of Systems Molecular Medicine (CoSMM) invited speaker  – Ayako Makino, PhD, Associate Professor, Department of Medicine, Division of Endocrinology and Metabolisms, The University of California, San Diego.  Presents “Coronary Microvascular Disease in Diabetes: Role of RNA-binding Protein, HuR” on Wednesday, August 28th,  2019 in the Physiology Conference Room, BSB 576.

Center of Systems Molecular Medicine (CoSMM) invited speaker – Myriam Fornage, PhD2019-08-01T20:02:39+00:00

Center of Systems Molecular Medicine (CoSMM) invited speaker  – Myriam Fornage, PhD, Professor of Molecular Medicine and Human Genetics from the University of Texas Health Science Center at Houston.  Presents “To the Crux of the Matter: Molecular Determinant of Cerebral Small Vessel Disease and its Risk factors” on Wednesday, May 22nd,  2019 in the Physiology Conference Room, BSB 576.

Center of Systems Molecular Medicine launches a MARS program for medicine and AI research2018-12-03T18:00:22+00:00

The Center of System Molecular Medicine (CoSMM), in collaboration with the Clinical and Translational Science Institute (CTSI) and the Institute for Health and Equity, has launched a Program for Medicine and AI Research (MARS) at MCW.  The MARS program will serve as an intellectual home for AI research at MCW to facilitate collaboration and project development.  Current members of the MARS program are involved in the research on machine learning methodologies, the application of AI in healthcare and medical and biomedical research, the ethics of AI, and educational implications of AI.

Please contact Kristin Nord (knord@mcw.edu) if you would like to be part of the MARS program.  Any MCW faculty, staff and student with an interest in AI research in medicine is welcome to join MARS.

Team science advances translational, systems molecular medicine research2018-07-19T15:18:45+00:00

July 17, 2018 MCW News – MCW translational research teams conducting systems molecular medicine research recently made discoveries that have the potential to benefit patients with cardiovascular disease, kidney disease and hypertension.

In one study, published in EMBO Molecular Medicine in 2018, a team of scientists from multiple departments discovered a novel mechanism for cardiovascular disease. They found that a molecule called miR-29 could restore the function of blood vessels from patients with diabetes and hypertension.

The scientists made the initial discovery by performing physiological and functional genomic analysis in human arterioles obtained through research biopsy. They then replicated the findings in animal models and identified the mechanistic pathway involved. Finally, the scientists went back to human arterioles and validated the mechanistic pathway.

In a second study, published in the Journal of the American Society of Nephrology in 2017, another team of scientists from multiple departments discovered new molecular patterns for four types of kidney disease in specific tissue regions in the kidney. They accomplished this by improving state-of-the-art deep sequencing techniques and applying them to analyze kidney specimens from about 100 patients.

In a third study, published in the Journal of the American Society of Nephrology in 2018, a team of scientists discovered a new molecular mechanism underlying hypertension in animal models by using functional genomic, physiological and molecular approaches. They demonstrated the potential importance of the mechanism in human hypertension by performing a systematic bioinformatic analysis of hundreds of sequence variations and thousands of genes in human and deep sequencing analysis of human specimens.

These studies were made possible by in-depth collaborations between physiologists, physicians, genomicists, molecular biologists, statisticians and bioinformaticians.

The vascular study was carried out by groups led by Dr. Michael Widlansky in the Department of Medicine’s Division of Cardiovascular Medicine, and Dr. Mingyu Liang in the Department of Physiology’s Center of Systems Molecular Medicine, with contributions from groups led by Drs. Aron Geurts, Alison Kriegel and Pengyuan Liu in the Department of Physiology.

The kidney disease study was carried out by Dr. Liang’s group in collaboration with Dr. Kenneth Iczkowski, in the Department of Pathology, and Dr. Kevin Regner, in the Department of Medicine’s Division of Nephrology.

The hypertension study was conducted by Dr. Liang’s group in collaboration with Drs. Liu, Geurts and Regner.

Many of these investigators are members of the Cardiovascular Center, the Genomic Sciences and Precision Medicine Center or the Cancer Center.

“I enjoyed working with my collaborators on these studies,” said Dr. Liang. “They are great scientists focusing on driving science forward and influencing medicine in significant ways. The work we have been able to do together is a testament to the strength of team science and systems molecular medicine research at MCW.”

Center of Systems Molecular Medicine (CoSMM) Announces a Special Seminar – David Calhoun, MD2017-09-21T20:37:38+00:00

Center of Systems Molecular Medicine (CoSMM) invited speaker  – David Calhoun, MD, Professor of Medicine from the University of Alabama at Birmingham.  Presents “Resistant Hypertension and Hyperaldosteronism: Cause and Effect” on Thursday, November 9th, 2017 in the Physiology Conference Room, BSB 576.

Center of Systems Molecular Medicine (CoSMM) Announces a Special Seminar – Bina Joe, PhD2017-10-05T19:21:17+00:00

 

Center of Systems Molecular Medicine (CoSMM) invited speaker  – Bina Joe, PhD, Professor and Chair of Physiology and Pharmacology from the University of Toledo College of Medicine and Life Sciences.  Presents “Inheritance of hypertension: Insights from Dahl Rats in Holy Toledo” on Wednesday, October 25th, 2017 in the Physiology Conference Room, BSB 576.

Center of Systems Molecular Medicine (CoSMM) Invited Speaker – Robin Felder, PhD2017-07-27T20:06:55+00:00

Center of Systems Molecular Medicine (CoSMM) invited speaker  – Robin Felder, PhD, Professor of Pathology from the University of Virginia School of Medicine.  Presents “The Etiology Behind Hypertension and Salt Sensitivity of Blood Pressure, New Diagnostics and Therapeutics” on Wednesday, August 30th, 2017 in the Physiology Conference Room, BSB 576.

CoSMM Center Director honored with 2017 Distinguished Lectureship Award2017-05-26T16:14:15+00:00

 

Mingyu Liang, M.D., Ph.D.

Director, Center of Systems Molecular Medicine (CoSMM)
Professor & Eminent Scholar
Department of Physiology
Medical College of Wisconsin

 

2017 Distinguished Lectureship Awardee in Physiological Genomics Research

Dr. Liang received his medical degree from Shanghai Medical University in 1994 and was named an Outstanding Graduate by the Shanghai Municipal Government. He entered Mayo Graduate School in Rochester, Minnesota, in 1996 and received a PhD in Biomedical Sciences (Physiology) in 1999 under the mentorship of Dr. Franklyn G. Knox. Following post-doctoral fellowships at Mayo Clinic with Dr. Karl A. Nath and the Medical College of Wisconsin (MCW) with Dr. Allen W. Cowley, Jr., Dr. Liang joined the faculty of MCW in 2002 and rose through the ranks to tenured Professor in 2011. He founded the Center of Systems Molecular Medicine (CoSMM) in 2014 at MCW and has held the title of Eminent Scholar (equivalent to Endowed Chair) at MCW since 2015. Dr. Liang’s laboratory studies microRNAs, cellular metabolism, epigenomics, and systems molecular medicine and precision medicine in the context of hypertension, cardiovascular, renal, and other diseases. His laboratory has made several contributions to the conceptual development, technological advances, and physiological and pathophysiological insights in these areas.  Dr. Liang has published nearly 100 papers. Dr. Liang received the 2012 Henry Pickering Bowditch Award, one of the highest honors bestowed by the American Physiological Society (APS).

Click here for more information.

AHA funds a $3.7M Hypertension Research Center at MCW.2017-04-04T18:17:28+00:00

Center of Systems Molecular Medicine (CoSMM) invited speaker – Christopher Mason, PhD2017-04-04T18:04:20+00:00

Center of Systems Molecular Medicine (CoSMM) invited speaker  – Christopher Mason, PhD, Associate Professor of Computational Genomics and Neuroscience from Weill Cornell Medicine.  Presents “Single-cell, City-scale, and Interplanetary Genomics” on Thursday, April 6th, 2017 in the Kerrigan Auditorium, MCW.

Center of Systems Molecular Medicine (CoSMM) Distinguished Lectureship – Curt D. Sigmund, PhD2017-04-04T18:32:25+00:00

Center of Systems Molecular Medicine (CoSMM) Distinguished Lectureship. “Novel Molecular Mechanisms Regulating Vascular Function” Given by Curt D. Sigmund, PhD – Chair and Department Executive Officer, Department of Pharmacology Professor & Roy J. Carver Chair in Hypertension Research Director, UIHC Center for Hypertension Research Rpy J. and Lucille A. Carver College of Medicine, University of Iowa. Wednesday, March 1st 3-4pm HRC Auditorium

Center of Systems Molecular Medicine (CoSMM), Human Molecular Genetics Center and Physiology invited speaker – Mark Knepper MD, PhD2017-04-04T18:33:10+00:00

Center of Systems Molecular Medicine (CoSMM), Human Molecular Genetics Center and Physiology Announce a Special Seminar! Mark Knepper MD, PhD Principal Investigator, Epithelial Systems Biology Laboratory, Division of Intramural Research, NHLBI, NIH, Bethesda MD 1.25.17 8:30am Physiology Conference room

Center of Systems Molecular Medicine (CoSMM) invited speaker – Rama Natarajan, PhD2017-04-04T18:33:46+00:00

Center of Systems Molecular Medicine (CoSMM) Announces a Special Seminar! Rama Natarajan, PhD Chair, Dept of Diabetes Complications & Metabolism Beckman Research Institute, Duarte CA.  “Epigenetics and non-coding  RNAs in Diabetic Nephropathy and Metabolic Memory” Friday October 28th 2-3pm Physiology Conference Room

Center of Systems Molecular Medicine (CoSMM) invited speaker – Pedro Jose, MD2017-04-04T18:11:47+00:00

Pedro Jose, MD, PhD Professor of Medicine and Physiology Division of Renal Disease & Hypertension present “Gastro-renal communication: role in hypertension” on Wednesday October 12th, 11:00 am CVC H4950

Center of Systems Molecular Medicine (CoSMM) invited speaker – Jingsong Chen, MD2017-04-04T18:31:01+00:00

Center of Systems Molecular Medicine (CoSMM) Announces a Special Seminar! Jingsong Chen, MD. “Human Tissues and Cells for Biomedical and Pharmaceutical Research” Tuesday August 23rd 10:00 am Physiology Conference room

Center of Systems Molecular Medicine (CoSMM) invited speaker – Justin L Grobe, PhD FAHA2017-04-04T18:14:41+00:00

Center of Systems Molecular Medicine (CoSMM) Announces a Special Seminar! Justin L Grobe, PhD FAHA

CoSMM investigator and collaborator obtained a translational, multi-PI R01 grant.2017-04-04T18:16:21+00:00

CoSMM investigator and collaborator obtained a translational, multi-PI R01 grant.  Dr. Michael Widlansky, Associate Chief for Academic Affairs, Division of CV Medicine, Director, Cardiovascular Medicine Fellowship, and Associate Professor of Medicine and Pharmacology, and CoSMM Director Dr. Liang are principal investigators on a multi-PI R01 grant from the NIH that started in September 2015.  Dr. Widlansky and Dr. Liang will collaborate closely to investigate the role of miRNAs in endothelial dysfunction in type 2 diabetes in this project.  The project is highly translational and integrated.  Approximately one half of the project will be performed in human subjects, and the other half in animal models.

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