The Center of Systems Molecular Medicine (CoSMM) at the Medical College of Wisconsin is an intellectual incubator for research and project development in molecular systems medicine.
Molecular systems medicine is an emerging discipline that is rooted in the recognition that humans are molecular systems. Humans are molecular systems in which molecules interact to take on emergent properties in the context of cells and organ systems. One must understand humans as molecular systems to understand human biology, health, and disease.
Recent Featured Publications
Multi-Omic Integration by Machine Learning (MIMaL)
Meyer and Colleagues, Bioinformatics, 2022
TOP-LD: A tool to explore linkage disequilibrium with TOPMed whole-genome sequence data
Auer and Colleagues, Am J Hum Genet., 2022
Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer
Liu and Colleagues, Nat Commun., 2022
Computational modeling of protracted HCMV replication using genome substrates and protein temporal profiles
Terhune and Colleagues, PNAS, 2022
KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells
Urrutia and Colleagues, Genome Biol, 2021
Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program
Auer and Colleagues, Am J Hum Genet, 2021
Dietary Sodium Restriction Results in Tissue-Specific Changes in DNA Methylation in Humans
Kidambi and Colleagues, Hypertension, 2021
KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBPβ Signaling Pathway
Lincoln and Colleagues, Circ Res, 2021
miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer
Chaluvally-Raghavan and Colleagues, Cell Rep , 2019
DriverML: a machine learning algorithm for identifying driver genes in cancer sequencing studies
Liu and Colleagues, Nucleic Acids Res, 2019
MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension
Liang and Colleagues, J Am Soc Nephrol, 2018
